A fcγriii-engaging bispecific antibody expands the range of

HIGHLIGHTS

• who: Top from the INSERM, CRCM, France have published the paper: A FcγRIII-engaging bispecific antibody expands the range of, in the Journal: (JOURNAL)
• what: The authors report the design of a Fab-like bispecific antibody (HER2bsFab) that displays a moderate affinity for and a unique specific and high affinity for FcγRIII.
• how: In an attempt to explain why HER2bsFab had no anti-proliferative effect the authors analyzed the impact of HER2bsFab on the activation of downstream MAPK and PI3K/AKT signaling pathways as these molecular events reflect HER2 activity (Fig . . .
  

   

  

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