Novel mimetic tissue standards for precise quantitative mass spectrometry imaging of drug and neurotransmitter concentrations in rat brain tissues

HIGHLIGHTS

• What: Methods using derivatization reagents have recently been developed for assessing the distribution of trace molecules such as neurotransmitters in the brain and are finding application in studies aimed at understanding molecular mechanisms in the brain . The authors focused on the technical evaluation of QMSI and for technical verification of QMSI, the authors evaluated the dynamic range, linearity (R2), limit of detection (LOD), relative error (%RE), relative standard deviation (%RSD), and stability at - 80 °C.
• Who: Kenichi Watanabe from the Preclinical Research Unit, Sumitomo Pharma Co [, ]Ltd., Osaka, Japan have published the research work: Novel . . .
  

   

  

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