High-resolution profile of neoantigen-specific tcr activation links moderate stimulation to increased resilience of engineered tcr-t cells

HIGHLIGHTS

• What: By enriching for CD137+ activated T_cells following specific stimulation with the neoantigens SYTL4S363F and KIF2CP13L and employing scTCR-seq (Fig 1a), the authors aimed to increase the sensitivity for detection of less frequent neoTCRs. Within this approach, the authors focused on the overall distribution of T_cell phenotypes across these defined clusters irrespective of their clonotype (Fig S2a-f). Subsequently, to investigate differences within the observed spectrum of activation, the authors focused on two TCRs with shared 7 Moderate TCR-signal associates with superior tumor control upon repeated neoantigen challenge in_vivo Aiming to understand the impact of . . .
  

   

  

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