Cortical lobar volume reductions associated with homocysteine-related subcortical brain atrophy and poorer cognition in healthy aging

HIGHLIGHTS

• What: This study built upon the previous work (Song et_al, 2023) in the same cohort of healthy older adults to investigate whether and how lobar regions of cortical brain volume are associated with the previously identified regional network covariance pattern that showed decreased SGM volumes of both the hippocampus and nucleus accumbens related to elevated plasma Hcy, as well as WMH burden. This study focused on predominantly healthy older adults who were able to perform a Effect and SE represent standardized coefficients and standard error, respectively, with TIV, sex, years of education, and the time interval between . . .
  

   

  

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