Circ-cdk8 regulates slc7a11-mediated ferroptosis by inhibiting mir-615-5p to promote progression in oral squamous cell carcinomas

HIGHLIGHTS

• What: In this study, the expression of circ-CDK8 in 43 pairs of OSCC tissues and paired normal tissues was analyzed. The authors report for the first time that circ-CDK8 regulates ferroptosis through the miR-615-5p/ SLC7A11 axis. This study provides a new potential therapeutic target for OSCC treatment. chemotherapy, and immunotherapy, with a 5-year survival rate of approximately 40%-60% (Mody et_al, 2021). The study showed that circPKD2 can promote autophagy by targeting miR-646, which promotes the sensitivity of OSCC cells to cisplatin chemotherapy (Gao et_al, 2019; Gao et_al, 2022).
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