Synthesis of 1,4 naphthoquinone derivatives and their in-silico evaluations

HIGHLIGHTS

• What: The authors explored the arylation of 1 with the help of Palladium acetate (Pd oAC). Traditional Brazilian medicine used lapachol and its cyclic derivatives, α- and β-lapachone, the authors show in FigNo2 as anti-inflammatory, antiseptic, antimalarial, antiparasitic, and anticancer medicines.
• Who: IEEE from the Translam Institute of Pharmaceutical Education and Research, Meerut UPIndia have published the Article: International Journal for Multidisciplinary Research (IJFMR), in the Journal: (JOURNAL)
• How: The following formula was used to get the inhibition constant (pKi) which was obtained from the ∆G parameter . ∆G=RT(Ln Kipred) Kipred=e . . .
  

   

  

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