HIGHLIGHTS
- What: The authors report that inflammasomes trigger the Gasdermin-D- and calcium-dependent eruption of filopodia from the plasma_membrane minutes before pyroptotic cell rupture, to crown the resultant corpse with filopodia. The authors propose that cells assemble filopodia before cell rupture to serve as a posthumous mark for a cell that has died by gasdermin-induced pyroptosis, or MLKL-induced necroptosis, for recognition by dendritic cells. This study reports that inflammasome signaling induces the coordinated assembly of F-actin-rich filopodia.
- Who: Caroline L. Holley from the (UNIVERSITY) have published the Article: Pyroptotic cell corpses . . .
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