Real-world effects of antidepressants for depressive disorder in primary care: population-based cohort study

HIGHLIGHTS

  • What: The authors compare real-world estimates with pooled, summary-level data available from equivalent RCTs to assess the degree of agreement between the two sources of evidence, and the existence of an efficacy-effectiveness gap in antidepressants. By using the value closest to the specified timepoint, the authors aimed to provide a more accurate representation of the individual`s status at that follow-up period. For this analysis, the authors used only the antidepressants that were studied in both databases, QResearch scientific committee reference 18/EM/0400, 1 July 2019. to 8.51) for mianserin. This . . .

     

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