Hsp105 inhibition downregulates store-operated calcium entry and promotes acute uvb-induced tight junction disruption

HIGHLIGHTS

• What: The authors used GSEA to assess the signaling pathways associated with HSP105. The analysis demonstrated a significant increase in the expression of HSP105, APG2, and GRP170 following acute UVB irradiation (Fig 1F). The authors initially investigated the effects of acute UVB exposure on the expression and distribution of tight junction proteins. The authors propose that CLDN4 is more susceptible to UVB-induced damage compared to CLDN1 and OCLN, with this susceptibility initially reflected in reduced transcript levels.
• Who: Kaiyi Zhou et al. from the Department of Dermatology, The First Affiliated Hospital of Chongqing Medical . . .
  

   

  

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