The impact of schizophrenia genetic load and heavy cannabis use on the risk of psychotic disorder in the eu-gei case-control and uk biobank studies

HIGHLIGHTS

• What: This study has been described in detail previously, see Bycroft et_al and Bycroft et_al . Given the differences in predictive power of polygenic scores across ancestry groups, the authors report a EUR-only sensitivity analysis in the online Supplementary materials. In models additionally adjusted for CUD PRS, the authors demonstrate that CUD PRS is also associated with case-control status in the EU-GEI cohort, with little evidence that the CUD PRS confounds the results for the schizophrenia PRS (difference in schizophrenia PRS OR for models with and without CUD PRS and amp;lt;10% in all . . .
  

   

  

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