Characterization of tumor-infiltrating lymphocytes and their spatial distribution in triple-negative breast cancer

HIGHLIGHTS

• What: This study was aimed to characterize the composition of TILs and investigate their clinicopathological and prognostic significance with a special focus on the spatial distribution of TILs in TNBCs. The study showed that CTL and NK cell-associated gene expression and protein levels differ significantly according to TIL levels and that CTL-NK score and distribution of TILs within tumors have a prognostic value. The authors aimed to conduct a comprehensive analysis of TIME in TNBC by comparing high versus low TIL-infiltrated tumors. Collectively, this study shows the importance of NK cells as well as . . .
  

   

  

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