Mutual activation of glutamatergic mglu4 and muscarinic m4 receptors reverses schizophrenia-related changes in rodents

HIGHLIGHTS

  • who: Paulina Cieu015blik from the Institute of Pharmacology, Polish Academy of Sciences, Smu0119tna St, Kraku00f3w, Poland Department of Pharmacology, Vanderbilt have published the research: Mutual activation of glutamatergic mGlu4 and muscarinic M4 receptors reverses schizophrenia-related changes in rodents, in the Journal: (JOURNAL) of 22/09/2010
  • what: In the present studies, the synergic antipsychotic action of mGlu4 and M4 receptor activation was investigated. In the present research, dose dependence studies showing activity of the compound in MK-801-based models of negative and cognitive symptoms of schizophrenia were carried out for the first time . . .

     

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