Rejuvenating bone marrow hematopoietic reserve prevents regeneration failure and hepatic decompensation in animal model of cirrhosis

HIGHLIGHTS

• What: In the hBMT group, out of the total LT-HSC population, only 0.5% at 24H and 1.2% at D11 were GFP+ LTHSCs; however, this population was undetectable at D21 Frontiers in Immunology Restoring the BM LT-HSC reserve accelerates the regression of fibrosis and regeneration Next, the authors aimed to determine whether the restoration of BM LTHSCs was associated with native liver repair or regeneration during cirrhosis. The authors demonstrate that loss of the BM-HSC reserve preceded regeneration failure and the onset of decompensated cirrhosis. The authors used a heterogeneous population of BM . . .
  

   

  

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