HIGHLIGHTS
- What: This study design is appropriate for investigating the association between smoking and DED in real-world smoker, and e-cigarette user; duration and intensity of settings; Publication language: Only studies published smoking): This information helps to characterize the in English were considered. The smoking status statistical test for asymmetry in the funnel plot. column describes the smoking groups being compared Sensitivity analyses were performed to assess the in each study; Four studies compare active smokers to robustness of the results by excluding studies with low non-smokers; Two studies compare e-cigarette users quality or small . . .

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