Shensu iv maintains the integrity of the glomerular filtration barrier and exerts renal protective effects by regulating endogenous hydrogen sulfide levels

HIGHLIGHTS

• What: On the day of final intervention (day 42), all the rats survived, the experiment was terminated by euthanasia with an overdose of pentobarbital sodium (200 mg/kg), and kidney tissues were collected for pathological examination. In response, this study explores the development of a new synthetic traditional Chinese medicine, Shensu IV, designed to protect kidney tissue. These areas will be the focus of the future research. The study demonstrates the potential efficacy of Shensu IV in regulating oxidative stress responses, ameliorating renal tissue pathology and function, and modulating protein expression through the PI3K/AKT signaling pathway . . .
  

   

  

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