Acute hepatitis of unknown aetiology in children: evidence for and against causal relationships with sars-cov-2, hadv and aav2

HIGHLIGHTS

• What: This work provides the first comprehensive assessment of all evidence on the 2022 cluster of paediatric hepatitis of unknown cause to date, with a view to informing clinical practice as well as further research in this area, should clusters of cases be observed again in the future. The aim of this study was to examine the role of SARS-­ CoV-­2, HAdv and AAV-­2 in paediatric hepatitis, using two approaches; applying the Bradford Hill criteria to evaluate the evidence for a causal relationship10 and examining the temporal association between HAdv and SARS-­CoV-­2 positivity . . .
  

   

  

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