Oleogels for the ocular delivery of epalrestat: formulation, in vitro, in ovo, ex vivo and in vivo evaluation

HIGHLIGHTS

• What: The aim of this work was to develop non-aqueous oleogels based on soybean oil and gelators from natural and sustainable sources (ethyl cellulose beeswax and cocoa butter) and to assess their reproducibility safety and efficiency in epalrestat release and permeation both ex vivo and in vivo. The aim of this work was to develop different oleogels The excitation wavelength was 532.188 nm, the sample was kept at a temperature of 8 °C during the experiment with a cooling plate, the laser power was 3 mW, and each point was measured with 60 accumulations with . . .
  

   

  

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