We should do better in accounting for multiple births in neonatal randomised trials: a methodological systematic review

HIGHLIGHTS

• What: The aims of this methodological systematic review were to determine if and how multiple births have been considered in the design, analysis and reporting of recent multicentre trials involving preterm infants and_(2) assess whether there has been an improvement since the last review was conducted 10 years ago . This methodological systematic review was conducted according to a prespecified protocol (online supplemental material 1). Consistently with the previous review on this topic the authors focused on preterm infants, where the definition of preterm was left to the individual trial, as multiple births are more common among . . .
  

   

  

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