HIGHLIGHTS
- What: This model shows a defective expression of NPP1, the main enzyme that generates PPi, caused by a nonsense_mutation in the corresponding gene . Unlike the models described above in which mutations are induced artificially, the progressive ankylosis (ank/ank) mouse is a strain with a spontaneous mutation in the Ank gene, that shows progressive impairment of joint mobility and extremely early arthritis with progressive unrelenting ectopic calcification and vertebral fusion conducing to death within 6 months of age .
- Who: Roberto Luisetto and Anna Scanu from the IRCCS Istituto Ortopedico Galeazzi, Italy Experimental Surgery Research Center . . .
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