Recent advance docking sites of novel phenothiazine’s derivative on g protein-coupled receptors (gpcrs) against depression with monoamine oxidase (pdb id: 2bxr)

HIGHLIGHTS

• What: The creation of phenothiazine hybrids is summarised in this study report. It has become necessary to incorporate the idea of drug-likeness at an early stage of drug discovery since an investigation into abandoned projects revealed that bad pharmacokinetic profiles and ADMET characteristics were the main reason of drug failure International Journal of Pharmaceutical Investigation, Vol 15, Issue 1, Jan-Mar, 2025 in the development stage . All of the composites in this investigation are active, but the most active derivatives A1, A8 and A18 with the least list affinity are identified as strong obstacles.
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