Exploration of first onsets of mania, schizophrenia spectrum disorders and major depressive disorder in perimenopause

HIGHLIGHTS

• What: The authors investigate whether the perimenopause (that is, the years around the final menstrual period (FMP)) is associated with increased risk of developing psychiatric disorders compared with the late reproductive stage. The authors focus on ‘late` first onsets, because studies on the effect of reproductive aging on firstonset severe mental illness (that is, schizophrenia spectrum disorders and bipolar disorder) are lacking. The authors aim to exploit a unique and specific asset of the UK Biobank: the combination of questions on first-onset psychiatric illness and age at FMP in an epidemiological study large enough to detect . . .
  

   

  

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