HIGHLIGHTS
- What: The authors explore the strategy of combining CDK4/6 and MEK inhibition in several models of RAS-mutated cancers. The authors conducted gene_expression analyses on RNAseq data obtained from publicly available datasets of HT1080 cells, three lung cancer, and three pancreatic cancer cell models.
- Who: Posted Date March and collaborators from the Research Institute (Toronto, ON, CAN)The pLenti0. UbCGWH BC1-PatGFP vector was obtained from Dr. Ethan Abel (RPCCC, Buffalo, NY, USA). Lentiviral infections were carried out in exponentially growing , or MIA PaCa, cells in the presence of polybrene (Sigma Aldrich, St. Louis . . .
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