Neuronal autosis is na+/k+-atpase alpha 3-dependent and involved in hypoxic-ischemic neuronal death

HIGHLIGHTS

• What: The authors evaluate the contribution of ATP1a1 and ATP1a3 subunits in neuronal autosis. Since the authors previously provided evidence for a pro-death role of enhanced autophagy mechanisms in different rodent models of acute perinatal brain injuries , this study aimed to Cell Death and Disease 15:363 investigate the involvement and the relevance of autosis in neurons, long-lived post-mitotic cells for which autophagy is of great importance to keep cell homeostasis and quality_control. The authors provide a step further, since several studies suggested that autophagy could regulate ferroptosis , the authors demonstrate that, in the . . .
  

   

  

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