Model-informed dose optimization of mycophenolic acid in pediatric kidney transplant patients

HIGHLIGHTS

• What: The authors aimed to develop and evaluate a population PK model of mycophenolic acid (MPA) in pediatric kidney transplant patients to aid MPA dose optimization. The main focus of the external evaluation was the correspondence of the individually predicted concentrations versus observed concentrations, as these reflect clinical practice where individual AUCs are assessed and dose adjustments are performed based on these AUCs. Study population of the model development dataset Data from 30 pediatric kidney transplant patients using MMF were used for model development. The model showed an underprediction on population level, yet adequate fit on the . . .
  

   

  

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