Structural domain in the titin n2b-us region binds to fhl2 in a force-activation dependent manner

HIGHLIGHTS

• What: In this study, the conformation of N2B-us and its interaction with four-and-a-half LIM domain protein 2 (FHL2) are investigated using AlphaFold2 predictions and single-molecule experimental validation. The studies have employed an integrated approach that combines AlphaFold2 structural and binding predictions with single- Nature Communications | 15:4496 shows low force does not affect bead height with 200 nM FHL2 (n=5, p=0.80), while high force leads to significant increases (n=5, p=0.0002). This study shows a powerful integration of AlphaFold2 prediction and single-molecule experiments to reveal the . . .
  

   

  

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