Regulation of dna replication within the immunoglobulin heavy-chain locus during b cell commitment

HIGHLIGHTS

• who: Commitment and collaborators from the Department of Oncology, Montefiore Medical Center, Moses Division, Bronx, New York, United States of America, Department of Physics, Simon Fraser University have published the research: Regulation of DNA Replication within the Immunoglobulin Heavy-Chain Locus During B Cell Commitment, in the Journal: (JOURNAL) of July/10,/2012
• what: The authors show that many aspects of DNA replication can be quantitatively explained by a mechanism involving the stochastic firing of origins (across the S phase and the Igh locus) and extensive variations in their firing rate (along the locus). The . . .
  

   

  

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