Agent-based model demonstrates the impact of nonlinear, complex interactions between cytokines on muscle regeneration

HIGHLIGHTS

• What: The aims of this work were to: 1) develop an ABM of muscle regeneration that includes cellular and cytokine spatial dynamics as well as the microvascular environment, 2) calibrate the model to capture cell behaviors from published experimental studies, 3) validate model outcomes by comparison with multiple published experimental studies, 4) conduct in silico experiments to predict how altering cytokine dynamics impacts muscle regeneration. The model has the capability to test and optimize various combinations of cytokines, along with exploring different temporal schedules for delivering specific treatments. The model provides advancements over prior models in three . . .
  

   

  

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