HIGHLIGHTS
- What: The analysis showed that R372 is vital for activity, possibly because of phosphate backbone interactions, whereas W373 may be involved in base interactions, which, if removed, could increase DNA separation capacity. This model is well in line with the biochemical data, showing that the XPD plug interacts with XPG, and with cross-linking data from Kokic et_al9, where peptides of the plug region were identified to interact with residues of XPG located adjacent to the C terminus of the catalytic region.
- Who: Jochen Kuper from the (UNIVERSITY) have published the research: XPD stalled on . . .
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