Ligand binding and subtype selectivity of the human a2a adenosine receptor

HIGHLIGHTS

• who: Veli-Pekka Jaakola from the (UNIVERSITY) have published the paper: Ligand Binding and Subtype Selectivity of the Human A2A Adenosine Receptor, in the Journal: (JOURNAL) of April/23,/2010
• what: The authors focus on residues shown to be important for ligand binding in the crystal_structure but for which no mutagenesis data has been previously reported, namely: Phe-168(5.29), Met-177(5.38), and Leu249(6.51). The authors characterize both the wild-type receptor and the mutated receptors for their functional activity (effects on cAMP production) and their ability to bind not . . .
  

   

  

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