Smoking, nicotine and pregnancy 2 (snap2) trial: protocol for a randomised controlled trial of an intervention to improve adherence to nicotine replacement therapy during pregnancy

HIGHLIGHTS

• What: The authors report the design of the RCT according to the Standard Protocol Items: Recommendations for Interventional Trial guidelines. ⇒ Participants are not blind to the treatments, and this could cause bias, which is limited by using biochemical verification of abstinence as the primary outcome. ⇒ Obtaining data on smoking abstinence from pregnant people who smoke is difficult; using routine data may ameliorate this. The authors report the protocol of SNAP2 according to the Standard Protocol Items: Recommendations for Interventional Trial guidelines.27 METHODS AND ANALYSIS SNAP2 is a multi-­ centre, parallel-­ group, individually randomised controlled trial (RCT . . .
  

   

  

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