HIGHLIGHTS
- What: The authors propose a mechanism for the intrinsic resistance of PDAC to ICIs; discuss the rationale for pursuing Treg-targeted therapies in the context of PDAC; and evaluate emerging strategies to limit Treg-mediated immunosuppression.
- Who: Helios and colleagues from the United States Heidelberg University Hospital, Germany have published the research: Manipulating regulatory T cells: is it the key to unlocking effective immunotherapy for pancreatic ductal adenocarcinoma?, in the Journal: (JOURNAL)
SUMMARY
Concomitantly, these studies have unearthed therapeutic targets that could feasibly be exploited to induce anti-tumour immunity in . . .
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