Identification and experimental validation of diagnostic and prognostic genes cx3cr1, pid1 and ptgds in sepsis and ards using bulk and single-cell transcriptomic analysis and machine learning

HIGHLIGHTS

  • What: This provides valuable insight into the overlapping mechanisms of sepsis and ARDS, offering a foundation for future studies aimed at improving diagnostic and treatment strategies for both conditions. This study explored the relationship between significant genes and TFs using the Cistrome database. Consistent with prior single-cell analysis results, the research demonstrated that sepsis advancement is associated with a decrease in lymphocytes, characterized by lower counts of CD8 and CD4 T_cells, B cells, and NK cells .
  • Who: Anupam Jyoti and collaborators from the Parul University, India have published the article: Identi fi cation and . . .

     

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