Sex-dependent intra-islet structural rearrangements affecting alpha-to-beta cell interactions lead to adaptive enhancements of ca2+ dynamics in prediabetic beta cells

HIGHLIGHTS

• What: Applying this approach, the authors have investigated in_vivo the pattern of beta cell i dynamics in beta cell functional adaptation in both sexes of a model of diet-induced type 2 diabetes, going from prediabetes to manifest diabetes. The authors focused on the 2 months WD feeding time point as both sexes retained the i dynamics compensatory mechanism described after glucose stimulation. The authors demonstrate increased alpha cell area and plasma glucagon levels in WD-fed mice during the compensatory phase. The study has some limitations that should be acknowledged.
• Who: Montse Visa from . . .
  

   

  

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