The effect of selinexor on prostaglandin synthesis in virus-positive merkel cell carcinoma cell lines

HIGHLIGHTS

• What: The study demonstrates that selinexor treatment of MCCP cell lines results in highly significant dosedependent reductions in the expression of COX enzymes, prostaglandin synthases (PGE2S), and downstream receptors (EP, PTGIR, PTGDR) in_vitro. The study provides insights into yet other mechanisms by which selinexor may inhibit carcinogenic pathways, potentially by inhibiting exportin transporters and impeding the relocation of MCPyV virally encoded tumor antigens to the cytoplasm, thus curtailing the dysregulation of downstream pathways.
• Who: Posted Date March et al. from the The University of Texas Health Science Center at Houston have published the research: The . . .
  

   

  

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