Secreted trimeric chikungunya virus spikes from insect cells: production, purification, and glycosylation status

HIGHLIGHTS

  • who: Tessy A. H. Hick and collaborators from the Laboratory of Virology, Wageningen University and Research, PB Wageningen, The Netherlands have published the article: Secreted Trimeric Chikungunya Virus Spikes from Insect Cells: Production, Purification, and Glycosylation Status, in the : Processes 2022, 162 of /2022/
  • what: The CHIKV envelope glycoproteins E1 and E2 are important immunogens; therefore the aim of this study is to produce CHIKV in insect cells using the baculovirus expression system. As the trimeric CHIKV spike strategy forms the perfect intermediate between subunit and VLP vaccines, the authors propose further development of BEVS . . .

     

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