Daxx-atrx regulation of p53 chromatin binding and dna damage response

HIGHLIGHTS

• who: Nitish Gulve from the The Wistar Institute, Philadelphia, PA, USA Weill School of Medicine, Cornell University, New York, NY, USA. have published the Article: DAXX-ATRX regulation of p53 chromatin binding and DNA damage response, in the Journal: (JOURNAL) of 12/Oct/2021
• what: The authors show that DAXX and ATRX knockout (KO) U87-T_cells that have acquired ALT-like features have defects in p53 chromatin binding and DNA damage response. The authors show specific examples of p53-binding_sites decreasing at the CDKN1A and GADD45A (Fig 4e), compared to not affected (MYOB3) or increasing . . .
  

   

  

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