HIGHLIGHTS
- who: Carlos Pulido-Quetglas and colleagues from the d`Investigacions Mediques (IMIM), Spain, Department of Clinical Research, University of have published the article: Scalable Design of Paired CRISPR Guide RNAs for Genomic Deletion, in the Journal: (JOURNAL) of December/30,/2016
- what: This approach has been widely adopted for diverse applications from disease modelling of individual loci to parallelized loss-of-function screens of thousands of regulatory elements. Using CRISPETa designs in human cells the authors show that predicted pairs of sgRNAs produce the expected deletions at high efficiency. The authors show that these deletions . . .
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