Synthesis and biological evaluation of dihydropyrano-[2,3-c]pyrazoles as a new class of ppar#_#x03b3; partial agonists

HIGHLIGHTS

  • who: Katrine Qvortrup and collaborators from the Department of Chemistry, Technical University of Denmark, Lyngby, Denmark, Center for Biological have published the paper: Synthesis and biological evaluation of dihydropyrano-[2,3-c]pyrazoles as a new class of PPAR#_#x03B3; partial agonists, in the Journal: PLOS ONE | DOI:10.1371/journal.pone [0162642]. February 28, 2017 of March/31,/2016
  • what: In this study, dihydropyran pyrazole 4 was identified as a promising PPARu03b3 partial agonist combining high inhibitor activity (IC50=0.03 mM) with a relatively poor induction of adipocyte differentiation. Unfortunately, due to . . .

     

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