A phylogeny-aware gwas framework to correct for heritable pathogen effects on infectious disease traits

HIGHLIGHTS

  • who: Sarah Nadeau from the Department of Biosystems Science and Engineering, ETH Zu00fcrich, Basel, Switzerland Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland have published the article: A Phylogeny-aware GWAS Framework to Correct for Heritable Pathogen Effects on Infectious Disease Traits, in the Journal: (JOURNAL)
  • what: The authors propose a new method to estimate and remove heritable pathogen effects on a trait based on the pathogen phylogeny prior to host GWAS, thus restoring independence of samples. In simulations, the authors show this additional step can increase GWAS power to detect . . .

     

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