Activation of innate-adaptive immune machinery by poly(i:c) exposes a therapeutic vulnerability to prevent relapse in stroma-rich colon cancer

HIGHLIGHTS

  • who: GI cancer et al. from the Research, Queen`s University have published the article: Activation of innate-adaptive immune machinery by poly(I:C) exposes a therapeutic vulnerability to prevent relapse in stroma-rich colon cancer, in the Journal: (JOURNAL)
  • what: Using in silico in vitro and in vivo models the authors demonstrate that the HPS is associated with antigen processing and presentation within discrete immune lineages in stroma-u00adrich CC downstream of double-u00adstranded RNA and viral response signalling. In line with previous studies, the authors demonstrate the ability of TGF-u03b2 signalling . . .

     

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