Adam17/egfr axis promotes transglutaminase-dependent skin barrier formation through phospholipase c γ1 and protein kinase c pathways

HIGHLIGHTS

• who: Cristina Wolfu2039u3274 from the DepartmentUniversity of Freiburg, Freiburg, Germany have published the research: ADAM17/EGFR axis promotes transglutaminase-dependent skin barrier formation through phospholipase C u03b31 and protein kinase C pathways, in the Journal: Scientific Reports Scientific Reports
• what: The authors focused the investigations on TG1 expression and activity. The authors provide new insights into the downstream mechanisms and demonstrate that ADAM17-driven EGFR signalling directly promotes TG1 expression and activity in keratinocytes committed to differentiation mainly via PLCu03b3u200b1 and PKC pathways.
• how: To further understand which of the epidermal PKC isoforms . . .
  

   

  

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