HIGHLIGHTS
- who: Siwei Zhang from the Department of Pharmacy, Pharmaceutical Biology, Ludwig-Maximilians-University, Munich, Germany, Department of Molecular Medicine, Max have published the article: Cdk5 controls lymphatic vessel development and function by phosphorylation of Foxc2, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS of 19/Dec/2013
- what: The authors show that cyclin-dependent kinase 5 (Cdk5) is an essential regulator of lymphatic vessel development. knockdown causes congenital lymphatic dysfunction and lymphedema due to defective lymphatic vessel patterning and valve formation. Mechanistically, the authors demonstrate that Cdk5 phosphorylates and regulates the activity of the transcription factor . . .
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