Generation of the first tcr transgenic mouse with cd4+ t cells recognizing an anti-inflammatory regulatory t cell-inducing hsp70 peptide

HIGHLIGHTS

• who: Femke Broere from the Department of Infectious Diseases and Immunology, Utrecht University, Utrecht, Netherlands USA have published the paper: Generation of the First TCR Transgenic Mouse with CD4+ T Cells Recognizing an Anti-Inflammatory Regulatory T Cell-Inducing Hsp70 Peptide, in the Journal: (JOURNAL)
• what: The authors aimed to generate a mouse model to study primary and naive Hsp70-specific CD4+ T_cells in more detail. The authors show that CD4+ T_cells from the mB29b-TCR transgenic mouse undergo antigen-specific proliferation and produce IL-2 after restimulation with B29 or its mouse homologs.
 



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