Pharmacological modulation of myeloid-derived suppressor cells to dampen inflammation

HIGHLIGHTS

  • who: Chiel van Geffen and collaborators from the United States University of Verona, Italy have published the paper: Pharmacological modulation of myeloid-derived suppressor cells to dampen inflammation, in the Journal: (JOURNAL)
  • what: This study shows the potential of targeting NF-kB and LRP2 to recruit MDSCs . Considering the negative role of MDSCs in the tumor microenvironment, one of the main goals of cancer research has been to suppress both MDSCs number and activity .
  • how: This review discusses pharmacological approaches involved in the generation recruitment and activation of MDSCs providing possible clues for . . .

     

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