Glioblastoma-derived macrophage colony-stimulating factor (mcsf) induces microglial release of insulin-like growth factor-binding protein 1 (igfbp1) to promote angiogenesis*

HIGHLIGHTS

• who: Mamatha Bangalore Nijaguna from the (Sigma-Aldrich, HPA000272), MCSF and , ELISA kit (RandD Systems have published the paper: Glioblastoma-derived Macrophage Colony-stimulating Factor (MCSF) Induces Microglial Release of Insulin-like Growth Factor-binding Protein 1 (IGFBP1) to Promote Angiogenesis*, in the Journal: (JOURNAL) of September/18,/2015
• what: This study shows up-regulation of MCSF in GBM via a SYK-PI3K-NF␬B-dependent mechanism and identifies IGFBP1 released by microglial cells as a novel mediator of MCSF-induced angiogenesis, of potential interest for developing targeted therapy to prevent GBM progression. The authors . . .
  

   

  

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