Generation of mitochondrial reactive oxygen species is controlled by atpase inhibitory factor 1 and regulates cognition

HIGHLIGHTS

  • who: Pau B. Esparza-Moltó and colleagues from the Cientı́ficas-Universidad Autónoma (CSIC-UAM), Spain, Centro have published the research work: Generation of mitochondrial reactive oxygen species is controlled by ATPase inhibitory factor 1 and regulates cognition, in the Journal: (JOURNAL) of May/13,/2021
  • what: The authors provide a comprehensive genetic demonstration that a large fraction of neuronal IF1 binds to and inhibits the ATP synthase in_vivo to regulate mitochondrial respiration and mtROS production. The authors focused on the IF1TG versus IF1KO comparison because it yielded the greatest number of differentially expressed . . .

     

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