Selective activation of gαob by an adenosine a1 receptor agonist elicits analgesia without cardiorespiratory depression

HIGHLIGHTS

• who: Mark J. Wall from the SchoolUniversity of DS, UK have published the paper: Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors show, utilising molecular dynamics (MD) simulations, and Gαi/o subunit- and β-arrestin-specific cellular signalling assays, how one A1R-selective agonist, BnOCPA33,34, fulfils the criteria for a selective Gα agonist in exclusively activating Gob among the six members of the Gαi/o family of G protein subunits, and in the absence of . . .
  

   

  

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