Evaluation at scale of microbiome-derived metabolites as biomarker of flavan-3-ol intake in epidemiological studies

HIGHLIGHTS

• who: from the gVL metabolites were analysed using UPLC-tandem MSDe novo synthesised authentic standards22, of the human gVL metabolites, (3′, ′-dihydroxyphenyl)-γ-valerolactone-3′-sulphate, (3′, ′-dihydroxyphenyl)-γ-valerolactone-3′-O-glucuronide, as well as an isotope labelled internal standard, C, (3′, ′-dihydroxyphenyl)-γ-valerolactone-3′-sulphate, were obtained from Analyticon (Analyticon Biotechnologies AG, Lichtenfels, Germany). Stock solutions were prepared in ethanol:water (70:30) and stored at , °C. Flavan-3-ol-metabolite-free urine was obtained from human-volunteers on a low flavan-3-ol diet. This study was approved by the University of Reading Research Ethics Committee . . .
  

   

  

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