Parp1 depletion induces rig-i-dependent signaling in human cancer cells

HIGHLIGHTS

  • who: Rajib Ghosh et al. from the Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America have published the paper: PARP1 depletion induces RIG-I-dependent signaling in human cancer cells, in the Journal: PLOS ONE | https://doi.org/10.1371/journal.pone [0194611]. March 28, 2018 of /1371/
  • what: The authors show that human cells surviving depletion of the Single Strand Break (SSB) repair protein PARP1 undergo p21-dependent senescence or cell cycle checkpoint activation in the context . . .

     

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