The rab11a-positive compartment is a primary platform for autophagosome assembly mediated by wipi2 recognition of pi3p-rab11a

HIGHLIGHTS

  • who: Claudia Puri from the Department of Medical Genetics, Wellcome Trust/MRC Building, Cambridge Biomedical Campus, Hills Road, Cambridge , XY, UK have published the research: The RAB11A-Positive Compartment Is a Primary Platform for Autophagosome Assembly Mediated by WIPI2 Recognition of PI3P-RAB11A, in the Journal: (JOURNAL)
  • what: The authors show that the PI3P signal is necessary but not sufficient to stabilize WIPI2 binding at the isolation membrane/RAB11A-positive membranes .

SUMMARY

    While the nature of the isolation membrane/autophagosome platform is still unclear, isolation membranes appear as membranes close to . . .

     

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